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Eye (Lond). 2011 Sep;25(9):1122-9. doi: 10.1038/eye.2011.174. Epub 2011 Aug 5.

Reconsidering the connection between vitamin D levels and age-related macular degeneration.

Author information

  • 1Department of Ophthalmology Tel Aviv Medical Center, Tel Aviv, Israel. shanigol2@walla.com

Abstract

PURPOSE:

Recent evidence has suggested a correlation between reduced vitamin D levels and delayed angiogenesis and reduced inflammatory response, which are known to have a major role in the development and progression of age-related macular degeneration (AMD).

DESIGN:

Cross-sectional study.

PARTICIPANTS:

Members of the Maccabi Healthcare Services (MHS, one of the four largest Israeli Health Maintenance Organization) aged ≥60 years, whose vitamin D levels were taken as part of routine examinations between 2000 and 2008.

METHODS:

All data for this study were obtained from MHS databases that include medical information on 1.8 million subscribers.

MAIN OUTCOME MEASURES:

Serum 25-OH vitamin D levels.

RESULTS:

The total study population comprised of 1045 members diagnosed as having AMD, and 8124 as non-AMD, for whom there was information on vitamin D levels. The mean±SD level of 25-OH vitamin D was 24.1±9.41  ng/ml (range 0.8-120) for the AMD patients and 24.13±9.50  ng/ml (range 0.0-120) for the controls (P=ns). One-third (33.6%) of the AMD patients and 32.86% of the controls had a 25-OH vitamin D level <16  ng/ml, and the proportions of tests in which the 25-OH vitamin D level was >74  ng/ml were 0.19 and 0.14%, respectively (P=ns).

CONCLUSIONS:

No association was detected between vitamin D levels and the presence of AMD in this cross-sectional study. These results raise some doubt about an association between reduced vitamin D levels and the prevalence of AMD.

PMID:
21818133
[PubMed - indexed for MEDLINE]
PMCID:
PMC3171790
Free PMC Article

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