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Mol Cell. 2011 Aug 5;43(3):319-21. doi: 10.1016/j.molcel.2011.07.016.

UneCLIPsing HuR nuclear function.

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  • 1Laboratory of Molecular Biology and Immunology, National Institute on Aging-Intramural Research Program, National Institutes of Health, Baltimore, MD 21224, USA.

Abstract

The RNA-binding protein HuR, while known to stabilize cytoplasmic mRNAs, is largely nuclear. In this issue of Molecular Cell, Mukherjee et al. (2011) and Lebedeva et al. (2011) identify transcriptome-wide HuR-RNA interactions using PAR-CLIP, unveiling HuR's nuclear role in pre-mRNA processing.

Copyright © 2011 Elsevier Inc. All rights reserved.

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PMID:
21816340
[PubMed]
PMCID:
PMC3156671
Free PMC Article

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