Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Biochimie. 2011 Nov;93(11):1916-21. doi: 10.1016/j.biochi.2011.07.024. Epub 2011 Jul 27.

Functional evidence of post-transcriptional regulation by pseudogenes.

Author information

  • 1Max-Delbrück Center for Molecular Medicine, Robert Rössle Str. 10, 13125 Berlin, Germany. enrique.muro@mdc-berlin.de

Abstract

Pseudogenes have been mainly considered as functionless evolutionary relics since their discovery in 1977. However, multiple mechanisms of pseudogene functionality have been proposed both at the transcriptional and post-transcriptional level. This review focuses on the role of pseudogenes as post-transcriptional regulators. Two lines of research have recently presented strong evidence of their potential function as post-transcriptional regulators of the corresponding parental genes from which they originate. First, pseudogene genomic sequences can encode siRNAs. Second, pseudogene transcripts can act as indirect post-transcriptional regulators decoying ncRNA, in particular miRNAs that target the parental gene. This has been demonstrated for PTEN and KRAS, two genes involved in tumorigenesis. The role of pseudogenes in disease has not been proven and seems to be the next research landmark. In this review, we chronicle the events following the initial discovery of the 'useless' pseudogene to its breakthrough as a functional molecule with hitherto unbeknownst potential to influence human disease.

Copyright © 2011 Elsevier Masson SAS. All rights reserved.

PMID:
21816204
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk