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Pharmaceuticals (Basel). 2009 Dec 3;2(3):150-167.

Mitochondrial Medicine and the Neurodegenerative Mitochondriopathies.

Author information

  • Departments of Neurology and Molecular and Integrative Physiology, University of Kansas School of Medicine, Kansas City, MO, Kansas 66160, USA; Tel.: +1-913-588-0685;

Abstract

Neurodegenerative diseases are a common late-life scourge for which disease-modifying treatments are sorely needed. Mitochondrial perturbation is commonly observed in these diseases, so pursuing treatment development strategies that target mitochondria or processes affected by mitochondria seems reasonable. This review discusses the rationale underlying past and current efforts to treat neurodegenerative diseases using mitochondrial medicine, and tries to predict how future efforts might proceed.

PMID:
21814473
[PubMed]
PMCID:
PMC3148068
Free PMC Article

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