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J Med Primatol. 2011 Oct;40(5):335-41. doi: 10.1111/j.1600-0684.2011.00495.x. Epub 2011 Aug 3.

A preliminary report on the feeding of cynomolgus monkeys (Macaca fascicularis) with a high-sugar high-fat diet for 33 weeks.

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  • 1Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, TX, USA. jmubiru@TxBiomed.org

Abstract

BACKGROUND:

The metabolic syndrome is common in populations exposed to a typical Western diet. There is a lack of an animal model that mimics this condition.

METHODS:

We fed 15 cynomolgus monkeys ad libitum a high-sugar high-fat (HSHF) diet for 33 weeks. Body weight, body composition, serum lipids, and insulin were measured at baseline and at 33 weeks.

RESULTS:

The animals tolerated the HSHF diet very well. In the intervention group, total serum cholesterol and low-density lipoprotein cholesterol were 3- and 5-fold higher, respectively, at 33 weeks as compared with their baseline levels. Serum high-density lipoprotein cholesterol and triglycerides were not significantly affected. Dual-energy X-ray absorptiometry (DXA) analysis of the intervention group indicated that the trunk fat mass increased by 187% during this period.

CONCLUSIONS:

Cynomolgus monkeys should be a useful model for investigating the interactions of diet and other factors such as genetics in the development of the metabolic syndrome.

© 2011 John Wiley & Sons A/S.

PMID:
21812784
[PubMed - indexed for MEDLINE]
PMCID:
PMC3282177
Free PMC Article
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