Send to:

Choose Destination
See comment in PubMed Commons below
J Med Primatol. 2011 Oct;40(5):335-41. doi: 10.1111/j.1600-0684.2011.00495.x. Epub 2011 Aug 3.

A preliminary report on the feeding of cynomolgus monkeys (Macaca fascicularis) with a high-sugar high-fat diet for 33 weeks.

Author information

  • 1Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, TX, USA.



The metabolic syndrome is common in populations exposed to a typical Western diet. There is a lack of an animal model that mimics this condition.


We fed 15 cynomolgus monkeys ad libitum a high-sugar high-fat (HSHF) diet for 33 weeks. Body weight, body composition, serum lipids, and insulin were measured at baseline and at 33 weeks.


The animals tolerated the HSHF diet very well. In the intervention group, total serum cholesterol and low-density lipoprotein cholesterol were 3- and 5-fold higher, respectively, at 33 weeks as compared with their baseline levels. Serum high-density lipoprotein cholesterol and triglycerides were not significantly affected. Dual-energy X-ray absorptiometry (DXA) analysis of the intervention group indicated that the trunk fat mass increased by 187% during this period.


Cynomolgus monkeys should be a useful model for investigating the interactions of diet and other factors such as genetics in the development of the metabolic syndrome.

© 2011 John Wiley & Sons A/S.

[PubMed - indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wiley Icon for PubMed Central
    Loading ...
    Write to the Help Desk