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Nanoscale. 2011 Sep 1;3(9):3788-92. doi: 10.1039/c1nr10518c. Epub 2011 Aug 3.

Growth of immobilized DNA by polymerase: bridging nanoelectrodes with individual dsDNA molecules.

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  • 1Nanoscience Center, Department of Physics, University of Jyväskylä, P.O. Box 35, FI-40014, Jyväskylä, Finland. veikko.linko@jyu.fi

Abstract

We present a method for controlled connection of gold electrodes with dsDNA molecules (locally on a chip) by utilizing polymerase to elongate single-stranded DNA primers attached to the electrodes. Thiol-modified oligonucleotides are directed and immobilized to nanoscale electrodes by means of dielectrophoretic trapping, and extended in a procedure mimicking PCR, finally forming a complete dsDNA molecule bridging the gap between the electrodes. The technique opens up opportunities for building from the bottom-up, for detection and sensing applications, and also for molecular electronics.

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