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Ann Saudi Med. 2011 Jul-Aug;31(4):360-4. doi: 10.4103/0256-4947.83215.

Relationship between circulating interleukin-10 and histological features in patients with chronic C hepatitis.

Author information

  • 1Department of Internal Medicine and Systemic Diseases, University of Catania, Catania, Italy. cmbruno@unict.it

Abstract

BACKGROUND AND OBJECTIVES:

An imbalance in cytokine production may be involved in the pathogenesis of chronic C hepatitis. The aim of the study was to investigate circulating levels of interleukin-10 (IL-10) in a selected cohort of patients affected by chronic C hepatitis.

DESIGN AND SETTING:

Retrospective study based on consecutive hepatitis C virus patients, affected by chronic active hepatitis, attending the general hospital of hepatology unit from June to September 2009

PATIENTS AND METHODS:

A total of 49 patients with chronic C hepatitis and 20 healthy control subjects similar in gender and age were examined. Circulating IL-10 was assessed by ELISA commercial kit (R and D Systems) in all investigated subjects.

RESULTS:

There was no significant difference in IL-10 values between controls and overall patients (P>.05). Nevertheless, among patients, subjects with more severe necroinflammation had higher values than others (P<.001). Moreover, a close relationship was found between IL-10 values and serum aspartate aminotransferase (r=0.61; P<.001).

CONCLUSIONS:

These findings suggest that IL-10 may be a useful additional marker to assess necroinflammation and to monitor the evolution of liver damage. They also argue for a potential pathophysiological role for IL-10 in the persistence and progression of hepatitis.

PMID:
21808111
[PubMed - indexed for MEDLINE]
PMCID:
PMC3156511
Free PMC Article

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