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Bioorg Med Chem. 2011 Sep 1;19(17):5167-74. Epub 2011 Jul 19.

Functionalized polystyrene supports for solid-phase synthesis of glycyl-, alanyl-, and isoleucyl-RNA conjugates as hydrolysis-resistant mimics of peptidyl-tRNAs.

Steger J, Micura R.

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Institute of Organic Chemistry and Center for Molecular Biosciences CMBI, University of Innsbruck, Innsbruck, Austria.

Abstract

RNA-peptide conjugates that mimic amino acid-charged tRNAs and peptidyl-tRNAs are of high importance for structural and functional investigations of ribosomal complexes. Here, we present the synthesis of glycyl-, alanyl-, and isoleucyladenosine modified solid supports that are eligible for the synthesis of stable 3'-aminoacyl- and 3'-peptidyl-tRNA termini with an amide instead of the natural ester linkage. The present work significantly expands the range of accessible peptidyl-tRNA mimics for ribosomal studies.

Copyright © 2011 Elsevier Ltd. All rights reserved.

PMID:: 21807524; [PubMed - indexed for MEDLINE]
PMCID:: PMC3162138

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