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    Cell. 1990 Apr 6;61(1):113-24.

    The macrophage and B cell-specific transcription factor PU.1 is related to the ets oncogene.

    Klemsz MJ, McKercher SR, Celada A, Van Beveren C, Maki RA.

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    Cancer Research Center, La Jolla Cancer Research Foundation, California 92037.

    Abstract

    We have isolated a cDNA clone, PU.1, that codes for a new tissue-specific DNA binding protein. Analysis of the binding site by methylation interference and DNAase 1 protection revealed that the PU.1 protein recognized a purine-rich sequence, 5'-GAGGAA-3' (PU box). The PU.1 protein was shown to be a transcriptional activator that is expressed in macrophages and B cells. cDNA constructions used to generate proteins lacking portions of either the amino- or carboxy-terminal ends of the PU.1 protein placed the DNA binding domain in the highly basic carboxy-terminal domain of the protein. The amino acid sequence in the binding domain of PU.1 has considerable identity with proteins belonging to the ets oncogene family.

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    PMID:
    2180582
    [PubMed - indexed for MEDLINE]

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