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Photochem Photobiol Sci. 2012 Jan;11(1):90-7. doi: 10.1039/c1pp05144j. Epub 2011 Aug 1.

UV wavelength-dependent DNA damage and human non-melanoma and melanoma skin cancer.

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  • 1Department of Cancer Biology, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA. gpfeifer@coh.org

Abstract

Ultraviolet (UV) irradiation from the sun has been epidemiologically and mechanistically linked to skin cancer, a spectrum of diseases of rising incidence in many human populations. Both non-melanoma and melanoma skin cancers are associated with sunlight exposure. In this review, we discuss the UV wavelength-dependent formation of the major UV-induced DNA damage products, their repair and mutagenicity and their potential involvement in sunlight-associated skin cancers. We emphasize the major role played by the cyclobutane pyrimidine dimers (CPDs) in skin cancer mutations relative to that of (6-4) photoproducts and oxidative DNA damage. Collectively, the data implicate the CPD as the DNA lesion most strongly involved in human cancers induced by sunlight.

This journal is © The Royal Society of Chemistry and Owner Societies 2012

PMID:
21804977
[PubMed - indexed for MEDLINE]
PMCID:
PMC3289542
Free PMC Article
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