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Exp Diabetes Res. 2011;2011:906154. doi: 10.1155/2011/906154. Epub 2011 Jul 24.

Obesity and blood pressure in 17-year-old offspring of mothers with gestational diabetes: insights from the Jerusalem Perinatal Study.

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  • 1Epidemiology Unit, Hebrew University Braun School of Public Health, Jerusalem, Israel.

Abstract

OBJECTIVE:

Gestational diabetes mellitus (GDM) influences fetal development and offspring's metabolic risk. We evaluated this association in 17-year-old offspring adjusting for birth weight (BW) and prepregnancy maternal BMI (mBMI).

STUDY DESIGN:

The JPS birth cohort contains extensive data on 92,408 births from 1964 to 1976. Offspring's BMI and blood pressure (BP) were obtained from military records. For a subcohort born between 1974 and 1976, prepregnancy mBMI was available. Offspring were classified as born to mothers with GDM (n = 293) or born to mothers without recorded GDM (n = 59,499).

RESULTS:

GDM offspring had higher mean BMI and systolic and diastolic BP compared to no-recorded-GDM offspring. After adjusting for BW, GDM remained significantly associated with offspring BMI and diastolic BP (β = 1.169 and 1.520, resp.). In the subcohort, when prepregnancy mBMI was entered to the models, it markedly attenuated the associations with GDM.

CONCLUSIONS:

Maternal characteristics have long-term effects on cardiometabolic outcomes of their offspring aged 17 years.

PMID:
21804818
[PubMed - indexed for MEDLINE]
PMCID:
PMC3143444
Free PMC Article
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