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Autophagy. 2011 Nov;7(11):1392-3. doi: 10.4161/auto.7.11.17347. Epub 2011 Nov 1.

A novel coatomer-related SEA complex dynamically associates with the vacuole in yeast and is implicated in the response to nitrogen starvation.

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  • 1CNRS UMR 8126, Universit√© Paris-Sud 11, Institut Gustave Roussy, Villejuif, France. svetlana.dokudovskaya@igr.fr


We now seem to live in a small world, in which everyone is highly interconnected. Cells, too, often also display tremendous interconnectivities in their component systems. As a recent case in point, we have identified a conserved protein complex--the SEA complex--that links the nuclear pore complex (NPC), the COPII vesicle coating complex, vacuoles and autophagy. In this punctum we will discuss the properties of this novel complex.

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