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Cell Metab. 2011 Aug 3;14(2):145-7. doi: 10.1016/j.cmet.2011.07.006.

The smoking gun in nicotine-induced anorexia.

Author information

  • 1Instituto de Investigaciones en Ingeniería Genética y Biología Molecular, Consejo Nacional de Investigaciones Científicas y Técnicas, Buenos Aires C1428ADN, Argentina. mrubins@dna.uba.ar

Abstract

Hypothalamic pro-opiomelanocortin (POMC) neurons are the major source of anorectic melanocortin peptides in the brain. A recent study (Mineur et al., 2011) demonstrates that nicotine directly stimulates arcuate POMC neurons through nicotinic acetylcholinergic α3β4 receptors, suggesting a new mechanism to understand the inverse relationship between tobacco smoking and body weight.

Copyright © 2011 Elsevier Inc. All rights reserved.

PMID:
21803282
[PubMed]
PMCID:
PMC3787252
Free PMC Article
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