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Cell. 2011 Aug 5;146(3):353-8. doi: 10.1016/j.cell.2011.07.014. Epub 2011 Jul 28.

A ceRNA hypothesis: the Rosetta Stone of a hidden RNA language?

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  • 1Cancer Genetics Program, Beth Israel Deaconess Cancer Center, Departments of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.

Abstract

Here, we present a unifying hypothesis about how messenger RNAs, transcribed pseudogenes, and long noncoding RNAs "talk" to each other using microRNA response elements (MREs) as letters of a new language. We propose that this "competing endogenous RNA" (ceRNA) activity forms a large-scale regulatory network across the transcriptome, greatly expanding the functional genetic information in the human genome and playing important roles in pathological conditions, such as cancer.

Copyright © 2011 Elsevier Inc. All rights reserved.

PMID:
21802130
[PubMed - indexed for MEDLINE]
PMCID:
PMC3235919
Free PMC Article
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