Enterovirus 68 among children with severe acute respiratory infection, the Philippines

Emerg Infect Dis. 2011 Aug;17(8):1430-5. doi: 10.3201/eid1708.101328.

Abstract

Enterovirus 68 (EV68) is a rare enterovirus associated with respiratory illness that, unlike other enteroviruses, has been identified only from respiratory specimens. We identified EV68 from respiratory specimens of children hospitalized with a diagnosis of severe pneumonia in Leyte, Republic of the Philippines. Twenty-one samples showed high similarity with EV68 by sequencing of 5' nontranslated region; 17 of these samples were confirmed as EV68 by sequencing of viral protein 1 capsid coding region. Most previously reported EV68 cases had been identified as sporadic cases. All 21 patients we identified had severe illness, and 2 died, possibly the first reported fatal cases associated with EV68 infection. Our study suggests that EV68 may be a possible causative agent of severe respiratory illnesses.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acute Disease
  • Adolescent
  • Child
  • Child Mortality
  • Child, Preschool
  • Enterovirus D, Human / classification
  • Enterovirus D, Human / genetics
  • Enterovirus D, Human / isolation & purification*
  • Enterovirus Infections / epidemiology*
  • Enterovirus Infections / mortality
  • Enterovirus Infections / physiopathology
  • Enterovirus Infections / virology
  • Female
  • Hospitalization / statistics & numerical data
  • Humans
  • Infant
  • Infant, Newborn
  • Male
  • Molecular Sequence Data
  • Philippines / epidemiology
  • Phylogeny
  • Pneumonia, Viral / epidemiology*
  • Pneumonia, Viral / mortality
  • Pneumonia, Viral / physiopathology
  • Pneumonia, Viral / virology
  • Polymerase Chain Reaction
  • Sequence Analysis, DNA
  • Severity of Illness Index

Associated data

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  • GENBANK/AB569898
  • GENBANK/AB569899
  • GENBANK/AB569900
  • GENBANK/AB569901
  • GENBANK/AB569902
  • GENBANK/AB569903
  • GENBANK/AB569904
  • GENBANK/AB569905
  • GENBANK/AB569906
  • GENBANK/AB569907
  • GENBANK/AB569908
  • GENBANK/AB569909
  • GENBANK/AB569910
  • GENBANK/AB569911
  • GENBANK/AB569912
  • GENBANK/AB569913
  • GENBANK/AB569914
  • GENBANK/AB569915
  • GENBANK/AB569916
  • GENBANK/AB569917
  • GENBANK/AB569918
  • GENBANK/AB569919
  • GENBANK/AB569920
  • GENBANK/AB569921
  • GENBANK/AB569922
  • GENBANK/AB569923
  • GENBANK/AB569924