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    Science. 1990 Mar 9;247(4947):1216-9.

    Control of the interferon-induced 68-kilodalton protein kinase by the HIV-1 tat gene product.

    Roy S, Katze MG, Parkin NT, Edery I, Hovanessian AG, Sonenberg N.

    Department of Biochemistry, McGill University, Montreal, Canada.

    The tat-responsive region (TAR) of the human immunodeficiency virus-1 (HIV-1) exhibits a trans-inhibitory effect on translation in vitro by activating the interferon-induced 68-kilodalton protein kinase (p68 kinase). Productive infection by HIV-1 was shown to result in a significant decrease in the amount of cellular p68 kinase. The steady-state amount of p68 kinase was also reduced in interferon-treated HeLa cell lines stably expressing tat, as compared to the amount of the kinase in interferon-treated control HeLa cells. Thus, the potential translational inhibitory effects of the TAR RNA region mediated by activation of p68 kinase may be downregulated by tat during productive HIV-1 infection.

    PMID: 2180064 [PubMed - indexed for MEDLINE]

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