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Pediatr Blood Cancer. 2012 Jun;58(6):836-9. doi: 10.1002/pbc.23274. Epub 2011 Jul 28.

MLL gene rearrangements in infant leukemia vary with age at diagnosis and selected demographic factors: a Children's Oncology Group (COG) study.

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  • 1University of Minnesota Masonic Cancer Center, Minneapolis, Minnesota.

Abstract

BACKGROUND:

Infant leukemias have a high frequency of mixed lineage leukemia (MLL) gene rearrangements.

PROCEDURE:

Using data from a large etiologic study, we evaluated the distribution of selected demographic factors among 374 infant leukemia cases by leukemic subtype, MLL status and diagnosis age.

RESULTS:

Overall, 228 cases were MLL+. Compared to white infants, black infants were significantly less likely to have MLL+ leukemia. Further, there was a statistically significantly higher age at diagnosis for infants with t(9;11) translocations compared to all other translocation partners in both acute lymphoblastic leukemia and acute myeloid leukemia cases.

CONCLUSION:

These patterns may provide important etiological insight into the biology of infant leukemia.

Copyright © 2011 Wiley Periodicals, Inc.

PMID:
21800415
[PubMed - indexed for MEDLINE]
PMCID:
PMC3208122
Free PMC Article

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