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Indian J Radiol Imaging. 2011 Apr;21(2):113-20. doi: 10.4103/0971-3026.82294.

Trans-arterial chemoembolization (TACE) in patients with unresectable Hepatocellular carcinoma: Experience from a tertiary care centre in India.

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  • 1Department of Radiodiagnosis, All India Institute of Medical Sciences, New Delhi, India.

Abstract

AIMS:

To evaluate the outcome following transarterial chemoembolization (TACE) and to identify the predictors of survival in patients with unresectable hepatocellular carcinoma (HCC).

MATERIAL AND METHODS:

HCC patients reporting to our hospital (2001-2007) were subjected to clinical, biochemical, and radiological examination. TACE was performed in those who fulfilled the inclusion criteria. Follow-up assessment was done with multiphase CT scan of the liver at 1, 3, and 6 months. Tumor response and survival rate were estimated. Univariate and multivariate analyses were done for determinants of survival.

RESULTS:

A total of 73 patients (69 males, 4 females; mean age 49±13.4 years) were subjected to 123 sessions of TACE. The Child's classification was: A - 56 patients and B - 17 patients. Barcelona Clinic staging was: A - 20 patients, B - 38 patients, and C - 15 patients. Tumor size was ≤5cm in 28 (38%) patients, >5-10 cm in 28 (38%) patients, and >10 cm in 17 (23%) patients. Median follow-up was for 12 months (range: 1-77 months). No significant postprocedure complications were encountered. Overall survival rate was 66%, 47%, and 36.4% at 1, 2, and 3 years, respectively. Tumor size emerged as an important predictor of survival.

CONCLUSION:

TACE offers a reasonable palliative therapy for HCC. Initial tumor size is an independent predictor of survival.

KEYWORDS:

Hepatocellular carcinoma; survival rate; transarterial chemoembolisation

PMID:
21799594
[PubMed]
PMCID:
PMC3137848
Free PMC Article
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