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Exerc Sport Sci Rev. 2011 Oct;39(4):199-205. doi: 10.1097/JES.0b013e31822d71be.

Role of p53 within the regulatory network controlling muscle mitochondrial biogenesis.

Author information

  • 1School of Kinesiology and Health Science, Muscle Health Research Centre, York University, Toronto, Ontario, Canada.

Abstract

The tumor suppressor protein p53 is recognized to contribute significantly to the regulation of mitochondrial content. Mice without p53 have reduced endurance capacity and muscle performance. However, the function of p53 in muscle remains to be fully established. Understanding how p53 coordinates mitochondrial homeostasis will facilitate a better comprehension of how exercise could constitute as a therapy for cancer treatment.

PMID:
21799424
[PubMed - indexed for MEDLINE]
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