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Curr Opin Infect Dis. 2011 Oct;24(5):472-7. doi: 10.1097/QCO.0b013e32834a88af.

Cholera in the 21st century.

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  • 1Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.

Abstract

PURPOSE OF REVIEW:

This review will focus on recent advances in our understanding of biologic and environmental factors that shape current cholera outbreaks, advances in our understanding of host-pathogen interactions during cholera, and recent evolution of current treatment and cholera prevention strategies.

RECENT FINDINGS:

New research studies have improved our understanding of a number of dynamic factors that shape the ecology of Vibrio cholerae and influence its transmission, including the role of lytic bacteriophage, biofilm formation, a hyperinfectious state of human-passaged V. cholerae, and the impact of severe weather events. Provision of safe water and improved sanitation continue to be the mainstays of preventing cholera transmission; however, the role of cholera vaccination as a control measure in both endemic and epidemic settings is evolving. Recent advances in our understanding of long-lived protective immunity after natural infection may aid in the global efforts to control cholera.

SUMMARY:

Improved understanding of factors associated with protective immunity and dynamic factors associated with cholera outbreaks may lead to improved control and prevention strategies for cholera.

PMID:
21799407
[PubMed - indexed for MEDLINE]
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