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    Science. 2011 Aug 26;333(6046):1144-7. Epub 2011 Jul 28.

    Nectins establish a checkerboard-like cellular pattern in the auditory epithelium.

    Togashi H, Kominami K, Waseda M, Komura H, Miyoshi J, Takeichi M, Takai Y.

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    Division of Molecular and Cellular Biology, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan.

    Abstract

    In the auditory epithelium of the cochlea, the sensory hair cells and supporting cells are arranged in a checkerboard-like fashion, but the mechanism underlying this cellular patterning is unclear. We found that mouse hair cells and supporting cells express the immunoglobulin-like adhesion molecules nectin-1 and -3, respectively, and that their interaction mediates the heterotypic adhesion between these two cell types. Genetic removal of nectin-1 or -3 disrupted the checkerboard-like pattern, inducing aberrant attachment between hair cells. When cells expressing either nectin-1 or -3 were cocultured, they arranged themselves into a mosaic pattern. Thus, nectin-1 and -3 promote the formation of the checkerboard-like pattern of the auditory epithelia.

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    PMID:
    21798896
    [PubMed - indexed for MEDLINE]

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