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J Pediatr. 2011 Dec;159(6):982-7.e1. doi: 10.1016/j.jpeds.2011.05.036. Epub 2011 Jul 27.

A randomized trial of 1- and 3-month depot leuprolide doses in the treatment of central precocious puberty.

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  • 1Drexel University College of Medicine, Philadelphia, PA, USA.

Abstract

OBJECTIVE:

To compare 1-month and 3-month depot formulations of leuprolide acetate (DL), a gonadotropin-releasing hormone analog, in the treatment of central precocious puberty (CPP).

STUDY DESIGN:

Subjects with CPP naïve to therapy were randomized to 7.5 mg of 1-month DL, 11.25 mg of 3-month DL, or 22.5 mg of 3-month DL. Stimulated luteinizing hormone (LH) and follicle-stimulating hormone (FSH) and estradiol levels, growth velocity, and bone age progression were examined in a 2-year period.

RESULTS:

Forty-nine female and 5 male subjects with CPP were randomized. Mean stimulated LH and FSH levels during treatment were higher in the low-dose 11.25-mg 3-month DL group, and more LH levels >4 IU/L were observed, in comparison with the other two dose groups. Mean LH and FSH levels in the 22.5-mg 3-month group were not different from the monthly DL. No differences in estradiol levels, growth velocity, or bone age progression were observed in dosing groups.

CONCLUSIONS:

All DL doses resulted in prompt and effective suppression of puberty, but higher LH and FSH levels were seen with the 11.25-mg 3-month DL dose. Multi-monthly DL is effective in treating CPP, but higher dosing may be required in some circumstances.

Copyright © 2011 Mosby, Inc. All rights reserved.

PMID:
21798557
[PubMed - indexed for MEDLINE]
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