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    Neurosci Lett. 2011 Sep 15;502(2):80-3. Epub 2011 Jul 20.

    Decision-making impairment in schizophrenia: relationships with positive symptomatology.

    Struglia F, Stratta P, Gianfelice D, Pacifico R, Riccardi I, Rossi A.

    Source

    Institute of Experimental Medicine, University of L'Aquila, Italy.

    Abstract

    Abnormal decision-making (DM) performance has been reported in several neurobehavioral disorders such as schizophrenia, addiction, and obsessive compulsive disorders. The exploration of DM correlates in terms of symptom formation may add more knowledge about the meanings of DM performance in schizophrenia. We examined the Iowa Gambling Task (IGT) and its relationship with clinical symptoms, evaluated by Positive and Negative Symptom Scale (PANSS), in 40 schizophrenic patients and 20 controls. Schizophrenic patients did worse on IGT performance with a significant difference between the two groups in Net Score. PANSS positive symptoms were negatively correlated with Net Score and advantageous choices and directly with disadvantageous choices. Results suggest that persons with schizophrenia display a pattern of compromised DM related to positive symptoms.

    Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

    PMID:
    21798312
    [PubMed - in process]

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