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Am J Drug Alcohol Abuse. 2011 Nov;37(6):487-90. doi: 10.3109/00952990.2011.598591. Epub 2011 Jul 29.

Bupropion-SR for smoking cessation in early recovery from alcohol dependence: a placebo-controlled, double-blind pilot study.

Author information

  • 1Department of Behavioral Science, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA. maherkaram@mdanderson.org

Abstract

We conducted a double-blind pilot study involving 11 alcohol- and nicotine-dependent patients randomized to receive either bupropion or placebo. Four of six patients on bupropion and one of five patients on placebo were abstinent from smoking at the end of medication phase. Those in the bupropion group reported significantly less craving (p < .02) and less exposure to cigarette smoke over time (expired carbon monoxide; p < .01). There were no serious adverse events and no main effects of medication group on either per subject or total number of adverse events. All those who completed treatment remained abstinent from alcohol.

PMID:
21797811
[PubMed - indexed for MEDLINE]
PMCID:
PMC4048722
Free PMC Article
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