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Reumatol Clin. 2008 Jul;4(4):136-9. doi: 10.1016/S1699-258X(08)71822-9. Epub 2008 Oct 28.

Correlation between cytokines and anxious-depressive symptoms in patients with fibromyalgia.

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  • 1Servicio de Inmunología, Hospital Universitario Virgen del Rocío, Sevilla, Spain.



To establish the influence of cytokines on anxious-depressive manifestations in fibromyalgia (FM) patients.


The study comprised 56 women (50.5±7.8 years) with FM and 32 healthy female controls (39.65±9.24 years). Psychiatric symptoms were analyzed using the Hamilton Depression Rating Scale (HDRS) and the Hamilton Anxiety Rating Scale (HARS), while pain was assessed by means of a Visual Analog Scale (VAS). Proinflammatory cytokines IL-6, IL-8, IL-10, and TNFα were assayed in serum using the Luminex-xMAP method. The statistical analysis was carried out using the SSPS statistical package.


IL-8 values were significantly lower (p=.013) in patients than in controls. No differences were observed among IL-6, IL-10, and TNFα levels. When comparing cytokine levels with patient age, we observed a significant reduction in IL-6, IL-8, and TNFα in older patients. The values of these cytokines showed no relationship to the anxious-depressive symptoms.


In our series no differences in serum cytokines were seen between patients with FM and controls, with the exception of a reduction in IL-8 among patients with FM, and which could be attributed to the older age of these patients.

Copyright © 2008 Elsevier España. Reumatología Clínica ® Sociedad Española de Reumatología and ® Colegio Mexicano de Reumatología. Published by Elsevier Espana. All rights reserved.

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