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Ann N Y Acad Sci. 2011 Jul;1229:29-37. doi: 10.1111/j.1749-6632.2011.06100.x.

Growth hormone-STAT5 regulation of growth, hepatocellular carcinoma, and liver metabolism.

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  • 1Laboratory of Genetics and Physiology, National Institutes of Health, Bethesda, Maryland, USA.


The liver is a primary target of growth hormone (GH). GH signals are mediated by the transcription factor signal transducer and activator of transcription 5 (STAT5). Here, we focus on recent discoveries about the role of GH-STAT5 signaling in hepatic physiology and pathophysiology. We discuss roles of the GH-STAT5 axis in body growth, lipid metabolism, and the cell cycle pertaining to hepatosteatosis, fibrosis, and hepatocellular carcinoma. Finally, we discuss recent discoveries about the role of GH-STAT5 in sex-specific gene expression and bile acid, steroid, and drug metabolism.

© 2011 New York Academy of Sciences.

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