Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Sci Signal. 2011 Jul 26;4(183):pe34. doi: 10.1126/scisignal.2002311.

Stem cell proliferation in the skin: alpha-catenin takes over the hippo pathway.

Author information

  • 1Department of Biochemistry and Molecular Biology, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA. elsaflores@mdanderson.org

Abstract

Epithelial tissues in the human body undergo constant renewal. For example, the skin is regenerated continuously through the periodic proliferation of normally quiescent stem cells in the basal compartment of the skin. Proper balance between stem cell quiescence and proliferation is maintained over the lifetime of the organism to preserve pools of stem cells required to maintain and repair tissues. However, mechanisms controlling the rate of stem cell renewal are poorly understood. Additionally, whether deregulation of these mechanisms within epidermal stem cells leads to skin cancer is not known. The adherens junction component α-catenin has been identified as a regulator of epidermal stem cell proliferation and as a suppressor of skin cancer through its inhibition of Yap, a transcriptional effector of the Hippo growth control pathway. Understanding the pathways that regulate the proliferation of stem cells in the skin holds promise for reversing the aging process and tumor development.

PMID:
21791701
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire
    Loading ...
    Write to the Help Desk