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One of the endothelin gene family, endothelin 3 gene, is expressed in the placenta.
Tsukuba Research Laboratories, Takeda Chemical Industries Ltd., Ibaraki, Japan.
A cDNA encoding human endothelin 3 (ET-3) precursor was cloned from a cDNA library from the placenta, and its nucleotide and deduced amino acid sequences were determined. This ET-3 cDNA was found to contain 2.3 kb pairs and encode prepro-ET-3 protein consisting of 224 amino acid residues. The putative big-ET-3 seems to consist of 42 amino acid residues. Two of the intron insertion sites were determined with information from nucleotide sequences of the cloned genomic ET-3 gene. This is the first direct evidence that the ET-3 gene is transcribed and expressed in the placenta.
PMID: 2178974 [PubMed - indexed for MEDLINE]
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Cited by 4 PubMed Central articles
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Ontogeny of endothelins-1 and -3, their receptors, and endothelin converting enzyme-1 in the early human embryo.
Brand M, Le Moullec JM, Corvol P, Gasc JM.
J Clin Invest. 1998 Feb 1; 101(3):549-59.
[J Clin Invest. 1998]
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Role of the neutral endopeptidase 24.11 in the conversion of big endothelins in guinea-pig lung parenchyma.
Lebel N, D'Orléans-Juste P, Fournier A, Sirois P.
Br J Pharmacol. 1996 Jan; 117(1):184-8.
[Br J Pharmacol. 1996]
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Differential localization of endothelin ETA and ETB binding sites in human placenta.
Rutherford RA, Wharton J, McCarthy A, Gordon L, Sullivan MH, Elder MG, Polak JM.
Br J Pharmacol. 1993 Jun; 109(2):544-52.
[Br J Pharmacol. 1993]
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