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Vet Med Int. 2011;2011:905153. doi: 10.4061/2011/905153. Epub 2011 Jul 12.

Antioxidants and the integrity of ocular tissues.

Author information

  • 1Escuela de Graduados, Facultad de Ciencias Veterinarias, Universidad Austral de Chile, P.O. Box 567, 5110566 Valdivia, Chile.

Abstract

Oxygen-derived free radicals are normally generated in many pathways. These radicals can interact with various cellular components and induce cell injury. When free radicals exceed the antioxidant capacity, cell injury causes diverse pathologic changes in the organs. The imbalance between the generation of free radicals and antioxidant defence is known as oxidative stress. The eye can suffer the effect of oxidative damage due to the etiopathogenesis of some pathological changes related to oxidative stress. This paper reviews the role of oxidative stress in the onset and progression of damage in different eye structures, the involvement of the antioxidant network in protecting and maintaining the homeostasis of this organ, and the potential assessment methodologies used in research and in some cases in clinical practice.

PMID:
21789267
[PubMed]
PMCID:
PMC3140028
Free PMC Article
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