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Environ Toxicol Pharmacol. 2010 Jan;29(1):3-6. doi: 10.1016/j.etap.2009.08.002. Epub 2009 Aug 22.

Frequency of chromosomal aberrations in peripheral lymphocytes of tannery workers in Brazil.

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  • 1Universidade de Franca, Avenida Dr. Armando Salles de Oliveira, 201 - Parque, Universitário, 14404-600 Franca, São Paulo, Brazil.


To evaluate the incidence of chromosomal aberrations (CA) in peripheral lymphocytes of workers chronically exposed to chemical hazards in a tannery in Franca, São Paulo, Brazil. The exposed group consisted of 10 male workers employed in the same tannery. The duration of work in the tannery ranged from 5 months to 14 years. The control group consisted of 10 males without a history of exposure to chemicals or other potentially genotoxic substances. A total of 100 well-spread metaphases were analyzed per subject. The frequency of CA was higher in the exposed group than in the control group. Smoking had a significant effect on the frequency of CA in both the control and the exposed groups. Chronic occupational exposure of tannery workers represents a relevant risk factor for the development of diseases associated with genetic damage.

Copyright © 2009 Elsevier B.V. All rights reserved.

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