Nat Med. 2011 Jul 24;17(8):941-3. doi: 10.1038/nm.2407.

Variants at 6q21 implicate PRDM1 in the etiology of therapy-induced second malignancies after Hodgkin's lymphoma.

Best T, Li D, Skol AD, Kirchhoff T, Jackson SA, Yasui Y, Bhatia S, Strong LC, Domchek SM, Nathanson KL, Olopade OI, Huang RS, Mack TM, Conti DV, Offit K, Cozen W, Robison LL, Onel K.

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Committee on Cancer Biology, University of Chicago, Chicago, Illinois, USA.

Abstract

Survivors of pediatric Hodgkin's lymphoma are at risk for radiation therapy-induced second malignant neoplasms (SMNs). We identified two variants at chromosome 6q21 associated with SMNs in survivors of Hodgkin's lymphoma treated with radiation therapy as children but not as adults. The variants comprise a risk locus associated with decreased basal expression of PRDM1 (encoding PR domain containing 1, with ZNF domain) and impaired induction of the PRDM1 protein after radiation exposure. These data suggest a new gene-exposure interaction that may implicate PRDM1 in the etiology of radiation therapy-induced SMNs.

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A step toward slaying the hydra of second cancers. [Nat Med. 2011]
A step toward slaying the hydra of second cancers.Morton LM, Chanock SJ. Nat Med. 2011 Aug 4; 17(8):924-5. Epub 2011 Aug 4.

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Variants at 6q21 implicate PRDM1 in the etiology of therapy-induced second malig...
Variants at 6q21 implicate PRDM1 in the etiology of therapy-induced second malignancies after Hodgkin's lymphoma.
Nat Med. 2011 Jul 24 ;17(8):941-3. doi: 10.1038/nm.2407.

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