Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Alzheimers Dement. 2011 Jul;7(4):e124-9. doi: 10.1016/j.jalz.2011.05.2412.

Genetic association of complement receptor 1 polymorphism rs3818361 in Alzheimer's disease.

Author information

  • 1Dementia Unit, University Hospital Virgen de la Arrixaca, Murcia, Spain.

Abstract

Complement receptor 1 gene polymorphism rs3818361 was recently shown to increase the risk of Alzheimer's disease (AD). We performed an independent replication study of this genetic variant in 2,470 individuals from Spain. By applying an allelic model, we observed a trend toward an association between this marker and late-onset AD susceptibility in our case-control study (odds ratio = 1.114, 95% confidence interval: 0.958-1.296, P = .16). Meta-analysis of available studies (n = 31,771 individuals), including previous studies and public genome-wide association study resources (Alzheimer's Disease Neuroimaging Initiative, Translational Genomics Research Institute, and Multi-site Collaborative Study for Genotype-Phenotype Associations in Alzheimer's Disease), strongly supports the effect of rs3818361 (odds ratio = 1.180, 95% confidence interval: 1.113-1.252, P < 2.99E-8) and suggests the existence of between-study heterogeneity (P < .05). We concluded that the complement receptor 1 gene may contribute to AD risk, although its effect size could be smaller than previously estimated.

Copyright © 2011 The Alzheimer's Association. Published by Elsevier Inc. All rights reserved.

PMID:
21784344
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk