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Mol Cell Endocrinol. 2012 Feb 5;349(1):13-9. doi: 10.1016/j.mce.2011.07.009. Epub 2011 Jul 18.

Circadian regulation of pineal gland rhythmicity.

Author information

  • 1Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA. borjigin@umich.edu

Abstract

The pineal gland is a neuroendocrine organ of the brain. Its main task is to synthesize and secrete melatonin, a nocturnal hormone with diverse physiological functions. This review will focus on the central and pineal mechanisms in generation of mammalian pineal rhythmicity including melatonin production. In particular, this review covers the following topics: (1) local control of serotonin and melatonin rhythms; (2) neurotransmitters involved in central control of melatonin; (3) plasticity of the neural circuit controlling melatonin production; (4) role of clock genes in melatonin formation; (5) phase control of pineal rhythmicity; (6) impact of light at night on pineal rhythms; and (7) physiological function of the pineal rhythmicity.

Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

PMID:
21782887
[PubMed - indexed for MEDLINE]
PMCID:
PMC3202635
Free PMC Article
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