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Immunity. 2011 Aug 26;35(2):260-72. doi: 10.1016/j.immuni.2011.06.005. Epub 2011 Jul 21.

Skin-resident murine dendritic cell subsets promote distinct and opposing antigen-specific T helper cell responses.

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  • 1Department of Dermatology, Center for Immunology, University of Minnesota, Minneapolis, MN 55455, USA.

Abstract

Skin-resident dendritic cells (DCs) are well positioned to encounter cutaneous pathogens and are required for the initiation of adaptive immune responses. There are at least three subsets of skin DC- Langerhans cells (LC), Langerin(+) dermal DCs (dDCs), and classic dDCs. Whether these subsets have distinct or redundant function in vivo is poorly understood. Using a Candida albicans skin infection model, we have shown that direct presentation of antigen by LC is necessary and sufficient for the generation of antigen-specific T helper-17 (Th17) cells but not for the generation of cytotoxic lymphocytes (CTLs). In contrast, Langerin(+) dDCs are required for the generation of antigen specific CTL and Th1 cells. Langerin(+) dDCs also inhibited the ability of LCs and classic DCs to promote Th17 cell responses. This work demonstrates that skin-resident DC subsets promote distinct and opposing antigen-specific responses.

Copyright © 2011 Elsevier Inc. All rights reserved.

PMID:
21782478
[PubMed - indexed for MEDLINE]
PMCID:
PMC3163010
Free PMC Article
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