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Department of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA. jhmorris@illinois.edu
Most of the steps in the blood clotting cascade require clotting proteins to bind to membrane surfaces with exposed phosphatidylserine. In spite of the importance of these protein-membrane interactions, we still lack a detailed understanding of how clotting proteins interact with membranes and how membranes contribute so profoundly to catalysis. Our laboratories are using multidisciplinary approaches to explore, at atomic-resolution, how blood clotting protein complexes assemble and function on membrane surfaces.
© 2011 International Society on Thrombosis and Haemostasis.
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