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Rev Soc Bras Med Trop. 2011 May-Jun;44(3):380-2.

Improvement of a PCR test to diagnose infection by Mansonella ozzardi.

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  • 1Coordenação de Medicina, Faculdade São Lucas, Porto Velho, RO, Brasil.

Abstract

INTRODUCTION:

Mansonelliasis is caused by Mansonella ozzardi. It is widespread in the Amazon region, with a high prevalence. The common exam of thick blood smears stained with Giemsa shows low efficacy levels and has been an obstacle to diagnosing individuals with low blood parasitemia.

METHODS:

In order to increase diagnosis efficacy, the PCR technique was improved.

RESULTS AND CONCLUSIONS:

PCR demonstrated the best performance, with sensitivity and negative predictive values (NPV) of 100%, followed by blood filtration through membrane filters, which showed a sensitivity of 88.9% and a NPV of 84.6%, when compared to thick blood smears.

PMID:
21779677
[PubMed - indexed for MEDLINE]
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