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Obesity (Silver Spring). 2011 Oct;19(10):1987-98. doi: 10.1038/oby.2011.230. Epub 2011 Jul 21.

Four-year weight losses in the Look AHEAD study: factors associated with long-term success.

Collaborators (396)

Brancati FL, Swartz L, Cheskin L, Clark JM, Stewart K, Rubin R, Arceci J, Bau S, Charleston J, Diggins D, Johnson M, Lambert J, Michalski K, Niggetts D, Sapun C, Bray GA, Rau K, Strate A, Greenway FL, Ryan DH, Williamson D, Armand B, Arceneaux J, Bachand A, Begnaud M, Berhard B, Caderette E, Cerniauskas B, Creel D, Duncan C, Guay H, Johnson C, Jones L, Kora N, LaFleur K, Landry K, Lingle M, Perault J, Puckett C, Shipp M, Smith M, Tucker E, Lewis CE, Thomas S, Safford M, DiLillo V, Bragg C, Dobelstein A, Gilbert S, Glasser S, Hannum S, Hubbell A, Jones J, Lee D, Luketic R, Oden L, Raines J, Roche C, Truman J, Webb N, Azuero C, King J, Morgan A, Nathan DM, Cagliero E, Hayward K, Turgeon H, Delahanty L, Anderson E, Bissett L, Goldman V, Harlan V, Michel T, Larkin M, Stevens C, Miller K, Chen J, Blumenthal K, Winning G, Tsay R, Cyr H, Pinto M, Horton ES, Jackson SD, Hamdy O, Caballero AE, Bain S, Bovaird E, Fargnoli B, Spellman J, Goebel-Fabbri A, Lambert L, Ledbury S, Malloy M, Ovalle K, Blackburn G, Mantzoros C, McNamara A, Spellman K, Hill JO, Miller M, Van Dorsten B, Regensteiner J, Coelho L, Cohrs P, Green S, Hamilton A, Hamilton J, Leshchinskiy E, Munkwitz L, Rome L, Worley T, Craul K, Smith S, Foreyt JP, Reeves RS, Pownall H, Balasubramanyam A, Jones P, Burrington M, Chen CH, Gardner AC, Gee M, Griggs S, Hamilton M, Holley V, Joseph J, Palencia J, Schmidt J, White C, Johnson KC, Gresham C, Connelly S, Brewer A, Coday M, Jones L, Lichtermann L, Vosburg S, Taylor JL, Kitabchi AE, Nyenwe E, Lambeth H, Brewer A, Clark D, Crisler A, Force D, Green D, Kores R, Jeffery RW, Thorson C, Bantle JP, Redmon JB, Crow RS, Crow S, Raatz SK, Brelje K, Campbell C, Carls J, Carmean-Mihm T, Devonish J, Finch E, Fox A, Hoelscher E, James LD, Maddy VA, Ockenden T, Rice BI, Skarphol T, Tucker AD, Voeller MS, Walcheck C, Pi-Sunyer X, Patricio J, Heshka S, Pal C, Allen L, Chong L, Gluck M, Hirsch D, Holowaty MA, Horowitz M, Rau N, Steinberg DB, Wadden TA, Maschak-Carey BJ, Berkowitz RI, Braunstein S, Foster G, Glick H, Kumanyika S, Schwartz SS, Allen M, Bell Y, Brock J, Brozena S, Carvajal R, Chomentowski H, Crerand C, Davenport R, Diamond A, Fabricatore A, Goldberg L, Hesson L, Hudak T, Iqbal N, Jones-Corneille L, Kao A, Kuehnel R, Lipschutz P, Mullen M, Jakicic JM, Kelley DE, Wesche-Thobaben J, Kuller LH, Kriska A, Otto AD, Ewing L, Korytkowski M, Edmundowicz D, Yamamoto ME, Danchenko R, Elnyczky B, Garcia DO, Grove GA, Harper PH, Harrier S, Helbling NL, Ives D, Mancino J, Mathews A, Murray TY, Ritchea JR, Urda S, Wolf DL, Wing RR, Bright R, Pera V, Jakicic J, Tate D, Gorin A, Gallagher K, Bach A, Bancroft B, Bertorelli A, Carey R, Charron T, Chenot H, Chula-Maguire K, Coward P, Cronkite L, Currin J, Daly M, Egan C, Ferguson E, Foss L, Gauvin J, Kieffer D, Lessard L, Maier D, Massaro JP, Monk T, Nicholson R, Patterson E, Phelan S, Raynor H, Raynor D, Robinson N, Robles D, Tavares J, Haffner SM, Montez MG, Lorenzo C, Coleman CF, Granado D, Hathaway K, Isaac JC, Ramirez N, Saenz R, Kahn S, Montgomery B, Knopp R, Lipkin E, Trence D, Barrett T, Bartell J, Greenberg D, Murillo A, Richmond BA, Socha J, Thomas A, Wesley A, Knowler WC, Bolin P, Killean T, Manus C, Krakoff J, Curtis JM, Glass J, Michaels S, Bennett PH, Morgan T, Begay S, Bloomquist P, Costa T, Fallis B, Hermes J, Hollowbreast DF, Johnson R, Meacham M, Nelson J, Percy C, Poorthunder P, Sangster S, Scurlock N, Shovestull LA, Smiley J, Toledo K, Tomchee C, Tonemah D, Peters A, Ruelas V, Sengardi SG, Hillstrom KM, Konersman K, Serafin-Dokhan S, Espeland MA, Bahnson JL, Wagenknecht LE, Reboussin D, Rejeski WJ, Bertoni AG, Lang W, Lawlor MS, Lefkowitz D, Miller GD, Reynolds PS, Ribisl PM, Vitolins M, Chen H, West DS, Friedman LM, Craven BL, Dotson KM, Hodges A, Williams CC, Anderson A, Barnes JM, Barr M, Beavers DP, Beckner T, Davis C, Del Valle-Fagan T, Feeney PA, Goode C, Griffin J, Harvin L, Hogan P, Gaussoin SA, King M, Lane K, Neiberg RH, Walkup MP, Wall K, Windham T, Nevitt M, Schwartz A, Shepherd J, Rahorst M, Palermo L, Ewing S, Hayashi C, Maeda J, Marcovina SM, Chmielewski J, Gaur V, Soliman EZ, Prineas RJ, Campbell C, Zhang ZM, Alexander T, Keasler L, Hensley S, Li Y, Moran R, Foushee R, Hall NJ, Evans M, Harrison B, Hubbard VS, Yanovski SZ, Kuczmarski R, Cooper LS, Kaufman P, Gregg EW, Williamson DF, Zhang P.

Author information

  • 1Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA. Wadden@mail.med.upenn.edu

Abstract

This report provides a further analysis of the year 4 weight losses in the Look AHEAD (Action for Health in Diabetes) study and identifies factors associated with long-term success. A total of 5,145 overweight/obese men and women with type 2 diabetes were randomly assigned to an intensive lifestyle intervention (ILI) or a usual care group, referred to as Diabetes Support and Education (DSE). ILI participants were provided approximately weekly group or individual treatment in year 1; continued but less frequent contact was provided in years 2-4. DSE participants received three group educational sessions in all years. As reported previously, at year 4, ILI participants lost an average of 4.7% of initial weight, compared with 1.1% for DSE (P < 0.0001). More ILI than DSE participants lost ≥ 5% (46% vs. 25%, P < 0.0001) and ≥ 10% (23% vs. 10%, P < 0.0001) of initial weight. Within the ILI, achievement of both the 5% and 10% categorical weight losses at year 4 was strongly related to meeting these goals at year 1. A total of 887 participants in ILI lost ≥ 10% at year 1, of whom 374 (42.2%) achieved this loss at year 4. Participants who maintained the loss, compared with those who did not, attended more treatment sessions and reported more favorable physical activity and food intake at year 4. These results provide critical evidence that a comprehensive lifestyle intervention can induce clinically significant weight loss (i.e., ≥ 5%) in overweight/obese participants with type 2 diabetes and maintain this loss in more than 45% of patients at 4 years.

PMID:
21779086
[PubMed - indexed for MEDLINE]
PMCID:
PMC3183129
Free PMC Article

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