Competing for the clamp: promoting RNA polymerase processivity and managing the transition from initiation to elongation

Grant A Hartzog; Craig D Kaplan

doi:10.1016/j.molcel.2011.07.002

Competing for the clamp: promoting RNA polymerase processivity and managing the transition from initiation to elongation

Mol Cell. 2011 Jul 22;43(2):161-3. doi: 10.1016/j.molcel.2011.07.002.

Authors

Grant A Hartzog¹, Craig D Kaplan

Affiliation

¹ Department of Molecular, Cell and Developmental Biology, University of California, Santa Cruz, CA 95064, USA. hartzog@biology.ucsc.edu

PMID: 21777806
DOI: 10.1016/j.molcel.2011.07.002

Abstract

Transcription elongation factor NusG/Spt5 spans the central cleft of RNA polymerase and functionally competes with transcription initiation factors. This work highlights the RNA polymerase clamp as a target for regulation and points to dynamic interactions between initiation and elongation machineries.

Publication types

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