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Nat Genet. 2011 Jul 24;43(8):741-3. doi: 10.1038/ng.877.

Analyses of X-linked and autosomal genetic variation in population-scale whole genome sequencing.

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  • 1Department of Biological Statistics and Computational Biology, Cornell University, Ithaca, New York, USA.

Abstract

The ratio of genetic diversity on chromosome X to that on the autosomes is sensitive to both natural selection and demography. On the basis of whole-genome sequences of 69 females, we report that whereas this ratio increases with genetic distance from genes across populations, it is lower in Europeans than in West Africans independent of proximity to genes. This relative reduction is most parsimoniously explained by differences in demographic history without the need to invoke natural selection.

PMID:
21775991
[PubMed - indexed for MEDLINE]
PMCID:
PMC3145052
Free PMC Article

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