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Genetics. 2011 Oct;189(2):549-60. doi: 10.1534/genetics.111.131714. Epub 2011 Jul 20.

emb-1 encodes the APC16 subunit of the Caenorhabditis elegans anaphase-promoting complex.

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  • 1Department of Biology, College of William and Mary, Williamsburg, Virginia, USA.

Abstract

In the nematode Caenorhabditis elegans, temperature-sensitive mutants of emb-1 arrest as one-cell embryos in metaphase of meiosis I in a manner that is indistinguishable from embryos that have been depleted of known subunits of the anaphase-promoting complex or cyclosome (APC/C). Here we show that the emb-1 phenotype is enhanced in double mutant combinations with known APC/C subunits and suppressed in double mutant combinations with known APC/C suppressors. In addition to its meiotic function, emb-1 is required for mitotic proliferation of the germline. These studies reveal that emb-1 encodes K10D2.4, a homolog of the small, recently discovered APC/C subunit, APC16.

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