Format

Send to

Choose Destination
See comment in PubMed Commons below
Am J Infect Control. 2012 Mar;40(2):123-7. doi: 10.1016/j.ajic.2011.04.001. Epub 2011 Jul 20.

Risk factors for acquisition of extended-spectrum β-lactamase-producing Escherichia coli in an urban county hospital.

Author information

  • 1Division of Infectious Diseases, Department of Internal Medicine, San Francisco General Hospital, University of California San Francisco, USA. sarah.doernberg@ucsf.edu

Abstract

BACKGROUND:

Better characterization of risk factors for extended-spectrum β-lactamase (ESBL)-producing bacteria is important for prevention, control, and treatment. This study aimed to identify risk factors for ESBL-producing Escherichia coli in a population of patients at an acute care urban teaching hospital.

METHODS:

A matched case-control study was performed. Cases comprised adults with ESBL E coli isolated from any source and matched with controls on year of hospitalization. One control group included patients with non-ESBL E coli, and a second control group consisted of patients with another resistant bacterium with well-characterized risk factors, Pseudomonas aeruginosa.

RESULTS:

There were 93 subjects in each group. Risk factors associated with ESBL cases compared with both control groups in a univariate model included sex, age, comorbidity, health care facility residence, recent hospitalization, and hemodialysis. In multivariate analysis, only Charlson comorbidity score remained significant between the cases and both control groups. Recent receipt of antibiotics was a risk factor for ESBL E coli versus non-ESBL E coli but not versus P aeruginosa.

CONCLUSIONS:

Underlying comorbid illness appears to be a robust risk factor for acquisition of ESBL-producing E coli. Antibiotic use is a less clear risk factor and may be a surrogate for health care exposure in general.

Copyright © 2012 Association for Professionals in Infection Control and Epidemiology, Inc. Published by Mosby, Inc. All rights reserved.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk