Send to:

Choose Destination
See comment in PubMed Commons below
Nat Immunol. 2011 Jul 19;12(8):695-708. doi: 10.1038/ni.2065.

Crosstalk in NF-κB signaling pathways.

Author information

  • 1Department of Microbiology & Immunology, Columbia University, College of Physicians & Surgeons, New York, New York, USA.


NF-κB transcription factors are critical regulators of immunity, stress responses, apoptosis and differentiation. A variety of stimuli coalesce on NF-κB activation, which can in turn mediate varied transcriptional programs. Consequently, NF-κB-dependent transcription is not only tightly controlled by positive and negative regulatory mechanisms but also closely coordinated with other signaling pathways. This intricate crosstalk is crucial to shaping the diverse biological functions of NF-κB into cell type- and context-specific responses.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Nature Publishing Group
    Loading ...
    Write to the Help Desk