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    JAMA. 2011 Jul 20;306(3):294-301.

    Hepatitis C virus infection and coinfection with human immunodeficiency virus: challenges and advancements in management.

    Hadigan C, Kottilil S.

    Source

    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA. hadiganc@niaid.nih.gov

    Abstract

    Hepatitis C virus (HCV) and human immunodeficiency virus (HIV) both emerged in the second half of the 20th century, and chronic infection with these agents is among the greatest challenges facing health care in the United States and worldwide. Despite tremendous advances in treatment and management of HIV and HCV, individuals with HIV/HCV coinfection experience a more complicated disease course and treatment. Recognition of the important role that host factors, such as IL28B genotype, have in response to HCV therapy and the emergence of new effective therapies for HCV are actively reshaping the standard of care. These advances may translate into more effective treatment and management of patients with chronic HCV and HIV coinfection in the years ahead.

    PMID:
    21771990
    [PubMed - indexed for MEDLINE]

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