J Gen Virol. 1990 Dec;71 ( Pt 12):3075-80.

Heptad repeat sequences are located adjacent to hydrophobic regions in several types of virus fusion glycoproteins.

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Department of Biological Sciences, University of Warwick, Coventry, U.K.

Abstract

Extensive regions of heptad repeat units consistent with an alpha-helical coiled coil conformation are located adjacent to hydrophobic, potentially fusion-related regions in the amino acid sequences of paramyxovirus fusion and retrovirus envelope glycoproteins. Similar arrangements of hydrophobic peptides and heptad repeat units exist in coronavirus peplomer proteins and influenza virus haemagglutinins. This suggests that there may be similarities in the structures of these proteins and in the functions of the hydrophobic fusion-related regions during virus entry.

PMID:: 2177097; [PubMed - indexed for MEDLINE]

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Comparative Study

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Viral Fusion Proteins

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