Send to:

Choose Destination
See comment in PubMed Commons below
Nord J Psychiatry. 2011 Dec;65(6):403-13. doi: 10.3109/08039488.2011.590603. Epub 2011 Jul 19.

A pharmacoeconomic analysis of sertindole in the treatment of schizophrenia in Sweden.

Author information

  • 1Department of Psychiatry, University Hospital , Uppsala , Sweden.



Atypical antipsychotics have similar clinical efficacy in the treatment of schizophrenia; variability in their tolerability represents the discerning factor in treatment choices. Sertindole has a relatively good tolerability profile that favours long-term patient adherence and, therefore, is associated with lower rates of relapse and rehospitalization.


A model was developed to compare the cost-effectiveness of a 5-year treatment strategy starting with sertindole versus olanzapine, risperidone, aripiprazole or the typical antipsychotic agent, haloperidol.


The model was based on published trials and local clinical practice, and considered costs from the perspective of the Swedish National Health Insurance Board.


All atypical agents were clinically superior and more cost-effective than haloperidol with a cost per quality-adjusted life year gained of approximately 490,000 Swedish kroner. Sertindole was associated with the lowest direct and indirect medical costs, driven by its tolerability profile.


Sertindole represents a useful alternative to the current treatment options available in Sweden.


The relatively good tolerability profile of sertindole translates into lower costs of schizophrenia management, primarily driven by substantially lower direct and indirect costs. Sertindole appears to be a clinically and cost-effective alternative in the management of patients with schizophrenia in Sweden.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Taylor & Francis
    Loading ...
    Write to the Help Desk