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Obstet Gynecol. 2011 Aug;118(2 Pt 2):486-9. doi: 10.1097/AOG.0b013e3182234d12.

Lymphoma in pregnancy initially diagnosed as vaginal intraepithelial neoplasia and lichen planus.

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  • 1Department of Obstetrics and Gynecology; Medicine, Division of Oncology; and Pathology, Stanford University School of Medicine, Stanford, California 94305-5317, USA.



Non-Hodgkin's lymphoma presenting as a vaginal mass in pregnancy is uncommon.


A 38-year-old primigravid woman presented at 27 weeks of gestation with vaginal lesions, bleeding, and discharge. Previous vaginal biopsies had been consistent with vaginal intraepithelial neoplasia 1 and lichen planus. After admission for this enlarging vaginal mass and bleeding, she was noted to have a newly palpable breast mass. Biopsy of the breast mass and subsequent re-evaluation of original vaginal biopsies were consistent with diffuse large B-cell lymphoma. She was treated with chemoimmunotherapy during pregnancy and delivered a viable neonate at term.


Although benign vaginal conditions are common, non-Hodgkin's lymphoma should be considered in the differential diagnosis of persistent or enlarging vaginal lesions in pregnancy.

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