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J Bacteriol. 2011 Oct;193(19):5520-6. doi: 10.1128/JB.05485-11. Epub 2011 Jul 15.

Characterization of components of the Staphylococcus aureus mRNA degradosome holoenzyme-like complex.

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  • 1Department of Microbiology and Immunology, University of Rochester Medical Center, School of Medicine and Dentistry, Box 672, 601 Elmwood Avenue, Rochester, NY 14642, USA.


Bacterial two-hybrid analysis identified the Staphylococcus aureus RNA degradosome-like complex to include RNase J1, RNase J2, RNase Y, polynucleotide phosphorylase (PNPase), enolase, phosphofructokinase, and a DEAD box RNA helicase. Results also revealed that the recently recognized RNase RnpA interacts with the S. aureus degradosome and that this interaction is conserved in other Gram-positive organisms.

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