Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Genes Dev. 2011 Jul 15;25(14):1470-5. doi: 10.1101/gad.2046711.

Nuclear factor I/B is an oncogene in small cell lung cancer.

Author information

  • 1David H. Koch Institute for Integrative Cancer Research,Department of Biology, Massachusetts Institute of Technology, Cambridge, USA.

Abstract

Small cell lung cancer (SCLC) is an aggressive cancer often diagnosed after it has metastasized. Despite the need to better understand this disease, SCLC remains poorly characterized at the molecular and genomic levels. Using a genetically engineered mouse model of SCLC driven by conditional deletion of Trp53 and Rb1 in the lung, we identified several frequent, high-magnitude focal DNA copy number alterations in SCLC. We uncovered amplification of a novel, oncogenic transcription factor, Nuclear factor I/B (Nfib), in the mouse SCLC model and in human SCLC. Functional studies indicate that NFIB regulates cell viability and proliferation during transformation.

PMID:
21764851
[PubMed - indexed for MEDLINE]
PMCID:
PMC3143937
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire Icon for PubMed Central
    Loading ...
    Write to the Help Desk