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Dev Cell. 2011 Jul 19;21(1):11-3. doi: 10.1016/j.devcel.2011.06.005.

Can a systems perspective help us appreciate the biological meaning of small effects?

Author information

  • 1Department of Biochemistry and Biophysics, California Institute of Quantitative Biosciences, University of California-San Francisco, CA 94158, USA. helsamad@gmail.com

Abstract

The study of dramatic phenotypes has been pivotal to elucidating biological mechanisms. Effectively approaching low-magnitude quantitative phenotypes, a common outcome of systematic loss-of-function studies, will be critical for understanding how individual components of cells interact to generate functioning systems.

Copyright © 2011 Elsevier Inc. All rights reserved.

PMID:
21763599
[PubMed - indexed for MEDLINE]
PMCID:
PMC3615985
Free PMC Article
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