Trends Cell Biol. 2011 Sep;21(9):552-9. Epub 2011 Jul 15.

Deciphering condensin action during chromosome segregation.

Source

European Molecular Biology Laboratory (EMBL), Meyerhofstrasse 1, 69117 Heidelberg, Germany.

Abstract

The correct segregation of eukaryotic genomes requires the resolution of sister DNA molecules and their movement into opposite halves of the cell before cell division. The dynamic changes chromosomes need to undergo during these events depend on the action of a multi-subunit SMC (structural maintenance of chromosomes) protein complex named condensin, but its molecular function in chromosome segregation is still poorly understood. Recent studies suggest that condensin has a role in the removal of sister chromatid cohesin, in sister chromatid decatenation by topoisomerases, and in the structural reconfiguration of mitotic chromosomes. In this review we discuss possible mechanisms that could explain the variety of condensin actions during chromosome segregation.

PMID:: 21763138; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Molecular Biology Databases

Saccharomyces Genome Database

Supplemental Content

Save items

Related citations in PubMed

Condensin is required for chromosome arm cohesion during mitosis. [Genes Dev. 2006]
Condensin is required for chromosome arm cohesion during mitosis.
Lam WW, Peterson EA, Yeung M, Lavoie BD. Genes Dev. 2006 Nov 1; 20(21):2973-84.
Contribution of hCAP-D2, a non-SMC subunit of condensin I, to chromosome and chromosomal protein dynamics during mitosis. [Mol Cell Biol. 2005]
Contribution of hCAP-D2, a non-SMC subunit of condensin I, to chromosome and chromosomal protein dynamics during mitosis.
Watrin E, Legagneux V. Mol Cell Biol. 2005 Jan; 25(2):740-50.
C. elegans condensin promotes mitotic chromosome architecture, centromere organization, and sister chromatid segregation during mitosis and meiosis. [Genes Dev. 2002]
C. elegans condensin promotes mitotic chromosome architecture, centromere organization, and sister chromatid segregation during mitosis and meiosis.
Hagstrom KA, Holmes VF, Cozzarelli NR, Meyer BJ. Genes Dev. 2002 Mar 15; 16(6):729-42.
Review The structure and function of SMC and kleisin complexes. [Annu Rev Biochem. 2005]
Review The structure and function of SMC and kleisin complexes.
Nasmyth K, Haering CH. Annu Rev Biochem. 2005; 74:595-648.
Review Sister chromatid resolution: a cohesin releasing network and beyond. [Chromosoma. 2010]
Review Sister chromatid resolution: a cohesin releasing network and beyond.
Shintomi K, Hirano T. Chromosoma. 2010 Oct; 119(5):459-67. Epub 2010 Mar 30.

See reviews... See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Deciphering condensin action during chromosome segregation.
Deciphering condensin action during chromosome segregation.
Trends Cell Biol. 2011 Sep ;21(9):552-9. Epub 2011 Jul 15 .

PubMed
Effect of a chronic treatment with 17β-estradiol on striatal dopamine neurotrans...
Effect of a chronic treatment with 17β-estradiol on striatal dopamine neurotransmission and the Akt/GSK3 signaling pathway in the brain of ovariectomized monkeys.
Psychoneuroendocrinology. 2012 Feb ;37(2):280-91. Epub 2011 Jul 16 .

PubMed
Spider bite.
Spider bite.
Lancet. 2011 Dec 10 ;378(9808):2039-47. Epub 2011 Jul 15 .

PubMed
Where does the interplay between cholesterol absorption and synthesis in the con...
Where does the interplay between cholesterol absorption and synthesis in the context of statin and/or ezetimibe treatment stand today?
Atherosclerosis. 2011 Aug ;217(2):308-21. Epub 2011 Jun 12 .

PubMed
Effect of dietary fish oil on atrial fibrillation after cardiac surgery.
Effect of dietary fish oil on atrial fibrillation after cardiac surgery.
Am J Cardiol. 2011 Sep 15 ;108(6):851-6. Epub 2011 Jul 15 .

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: